Strategic Research

Computational Biology of RNA processing

The overarching theme of the research in our group is the understanding of the information encoded in genomic sequences, and how this information is processed in the pathway leading from DNA to protein sequences.

Ongoing Research Projects

  • Gene prediction and Genome projects. The group participates in many international genome sequencing projects, through the expertise in gene finding and genome annotation
  • Prediction of Selenoproteins. Selenoproteins are proteins that incorporate selenocysteine, Sec,  the 21st amino acid.  Sec is encoded by the codon UGA, normally a stop codon, which makes the prediction of selenoproteins challenging. Our group is developing methods to predict selenoprotin genes.
  • Transcritpional analysis. Most of the efforts in our group are in the analysis of RNA production and post-processing, and in the relation between tissue transcriptomes and phenotypes. We participate in the ENCODE, GTEx and BluePrint projects. We are also funded by the ERC to investigate the genetic and epigenetic determinants of RNA processing.

Main projects

  • 1.

    ENCODE project. “Landscape for transcription in human and mouse"

    Generating high resolution transcriptional maps in many diverse human cell lines and tissues (funded by NIH/NHGRI). Including the GENCODE project

  • 2.

    GTEX project. “Methods for high-resolution analysis of genetic effects on gene expression”

    The goal of this project is to develop statistical methods to analyze the data produced by the Genotype Tissue Expression (GTEx) project (funded by NIH/NHGRI).

  • 3.


    The goal of this project is to decipher the genetic and epigenetic determinants of RNA production and post-processing (funded by the EC)



Bioinformatics expertise:

Group Leader:

Roderic Guigó

Bioinformatics services offered