Strategic Research

Protein Folding and Conformational Diseases (PFCD)

The long-term goal of our research is to contribute to decipher the mechanisms of protein homeostasis in the cell. We use a combined computational and experimental approach to address fundamental aspects of protein folding, misfolding and aggregation. In addition to define the basic mechanistic principles underlying these processes, we aim to understand how their deregulation leads to the onset of a series of human conformational disorders, which include neurodegenerative diseases, but also diabetes or cancer. This knowledge should ultimately pave the way for the development of novel therapeutic strategies to target these devastating pathologies

Main projects

  • 1.

    Deciphering the role of alpha-synuclein strains in prion-like synucleopathy induction and Spreading

    Ref. 20144330. Fundación La Marato de TV3. Spain

  • 2.

    Discovery, Characterization and Design of New Functional Self-Templating Amyloids

    BFU2013-44763-P. Ministerio de Economia y Competitividad. Spain

  • 3.

    Developing a drug to treat transthyretin amyloidosis.

    RTC-2014-1931-1. Ministerio de Economia y Competitividad. Spain

Bioinformatics services offered