Strategic Research

Functional Genomics group of GRIB

The Functional Genomics group aims at narrowing the gap between sequence and function by developing computational tools to build network models of molecular regulatory mechanisms from high-throughput genetics and genomics data. The group is interested in the problem of reverse-engineering the genotype-phenotype map trying to embrace the complexity that follows from the coordinated action of genes and other molecules by means of multivariate statistical models, such as graphical Markov models.

The Functional Genomics  group of GRIB, led by Robert Castelo, is integrated in the Research Programme on Biomedical Informatics, GRIB. The GRIB is a joint research programme of the Hospital del Mar Medical Research Institute (IMIM) and the Department of Experimental and Health Sciences of the Universitat Pompeu Fabra. The GRIB mission is to develop and apply computational methods and information technologies for a better understanding and prediction of biological phenomena, giving especial emphasis to those related to the human diseases, their prevention, diagnosis and pharmacological treatment. 

Main projects

  • 1.

    Limited-order graphical Markov models in integrative genomics (LOGx)

    2016-2018. (TIN2015-71079-P) MINECO.

  • 2.

    European Cooperation for Statistics of Network Data Science (COSTNET)

    2016-2019 (CA15109) EU Framework Programme H2020



Bioinformatics expertise:

Group Leader:

Robert Castelo



Chus Donlo

Bioinformatics services offered