Computational PhD Student on single-cell transcriptomics

Centre / Institution:
Bellvitge Biomedical Research Institute
Bioinformatics expertise:

Job description

IDIBELL is looking for a highly motivated computational student to pursue a Ph.D. in the Gene Regulation of Cell Identity Group.

The successful candidate will work on a research project focused on the role of RNA binding proteins (RBPs) in post-transcriptional gene regulation and cell type specification during neural differentiation using single-cell transcriptomics and other high-throughput omics methods. For this purpose, the candidate will be expected to analyze single-cell RNA-seq datasets and develop new computational approaches to study the function of RBPs in these data.

Research at the Gene Regulation of Cell Identity Group, led by Dr. Mireya Plass, aims at understanding how post-transcriptional regulatory mechanisms and their regulators, mainly RBPs and microRNAs, are involved in the establishment of cellular identity and how their dysregulation contributes to the development of neurodegenerative diseases. For this purpose, we use induced pluripotent stem cells (iPSCs) to model neural differentiation in humans and study their differentiation process using a combination of molecular biology techniques with high-throughput omics and computational tools.

Desired skills and expertise

We are looking for a candidate with a background in biology, computer science, physics or similar with a strong background in bioinformatics and experience in high-throughput sequencing data analyses. Candidates are expected to have experience in R and a scripting language such as Python or Perl. Prior knowledge on single-cell transcriptomics, post-transcriptional regulation or method development will be considered. Interest in gene regulation and working in a multidisciplinary team will be valued, as interaction with experimental researchers will be required for the success of the project.

Required information and contact

All applications must include the following:

·         A motivation letter addressed to Dr. Mireya Plass

·         A full academic CV including contact information and transcript of academic records

·         Contact details of two referees

All applications must be submitted to jobs(ELIMINAR) For informal inquiries, please contact directly to Dr. Plass at mplass(ELIMINAR)