Bioinformatics involved in identifying a potential target to treat lung cancer at IRB Barcelona
Researchers at IRB Barcelona, a BIB member, have discovered that the HMCES enzyme is very effective against lung tumours with a higher number of mutations caused by the APOBEC system (an antiviral defence mechanism).
The study, led by Dr Travis Stracker and Dr Fran Supek, comprises both computational and experimental approaches and is the result of the collaboration between two research groups working on different disciplines. Genetic screening experiments were performed using CRISPR/Cas9 on several types of human lung adenocarcinoma cell lines.
Personalised medicine takes advantage of the unique genetic changes in an individual tumour to find its vulnerabilities and fight it. However, the APOBEC system can accidentally damage DNA and cause a higher number of mutations in the tumour.
In this context, IRB Barcelona is organizing The Metastasis Challenge to raise money in support of the research into metastasis.
More info about this study here.